Endocrine Abstracts

Introduction: Type 2 amiodarone-induced thyrotoxicosis (AIT2), resulting from the release of thyroid hormones, is a rarer form of side effect of this drug. Treatment of thyrotoxicosis in patients with end stage renal disease (ESRD) is difficult because hemodialysis alters renal clearance of drugs and iodine, may impact the results of assessment and treatment and can increase the medical instability of patients.Aim: The aim was to present the difficulties...

Introduction: Hypopituitarism is characterized by the absence of pituitary hormones. Depending on what pituitary hormones are missing and what is the etiology of hypopituitarism, its clinical manifestation varies. Apart from evident symptoms and signs of hypopituitarism due to hormonal insufficiencies, several studies reveal that long-standing hypopituitarism, including particularly absence of GH, is related to higher risk of metabolic syndrome.Objective...

Introduction: Radioiodine (RAI) has been used for the treatment of Graves’ hyperthyroidism since 1940s. It is relatively safe and considered as one of the definitive therapies. Achievement of hypothyroidism or euthyroidism is defined as a successful therapy.Methods: The study was conducted in 366 patients (80.60% of women) with Graves’ disease (GD), aged 46.76±13.52 years. We analyzed retrospectively hormonal and imaging findings (scintigr...

Introduction: Radioiodine (RAI) is used as a definitive therapy of hyperthyroidism due to toxic adenoma (TA) as well as toxic multinodular goiter (TMG). Achievement of hypothyroidism or euthyroidism is defined as a successful therapy.Methods: The study was conducted in 666 patients – 484 with TA and 182 with TMG (85.58% of women), aged 56.19±13.88 years. We analyzed retrospectively hormonal and imaging findings (scintigraphy, ultrasonography), ...

Introduction: Temozolomide (TMZ) can be administered as the last therapeutic option for aggressive pituitary tumors. Dopamine-agonist resistant prolactinomas are relatively frequent and remain a serious therapeutic problem. GH expressing atypical adenomas are rare and their positive response to TMZ is low. In a general opinion a lack of response to TMZ after three cycles predicts the treatment resistance.The aim of the study was presentation of two patie...

Introduction: The empty sella syndrome (ESS) is defined as the penetration of the subarachnoid space into intrasellar region. In ESS pituitary hormonal function is usually normal, but several, mostly subtle, hormonal abnormalities have been also reported. The coexistence of Cushing’s disease and primary empty sella is very rare.Objective: The presentation of an exceptional case of a patient with Cushing’s disease associated with primary empty s...

Introduction: Crooke’s cells are normal corticotrophs with cytoplasmic accumulation of cytokeratin filaments in response to glucocorticoids excess. Crooke’s cell corticotropinomas are the unique cause of Cushing’s disease. Nearly all of them are invasive macroadenomas, generally aggressive, refractory to conventional therapy, with high recurrence rate.Aim of the study was to present a case study of a patient with Cushing’s disease cau...

Introduction: Aggressive corticotropinomas are more invasive than other pituitary tumors. Recent reports have documented the efficacy of temozolomide alone or in combination with an anti-angiogenic agent –bevacizumab in invasive pituitary adenomas treatment.Objective: Presentation a case of 56-year-old woman initially diagnosed as Cushing’s disease and the analysis of treatment procedures with special concentration on temozolomide and bevacizum...

Introduction: Acromegaly is a rare endocrinopathy which shows characteristic phenotypic and metabolic features. Primarily patients in their forties or fifties suffer from this disorder but the main problem is late diagnosis, especially in men, even 10 years after the first symptoms. We present an unusual clinical course of acromegaly with no phenotypic features to stress the need to perform complete evaluation of endocrine function in hypogonadal patients.<p class="abstext...

Introduction: Carbohydrate disorders in the form of glucose intolerance or overt diabetes are prevalent and well-documented in acromegalic patients.Aim: To assess the prevalence of carbohydrate disorders and the correlations between BMI, the duration of the disease, GH and IGF-1 concentrations depending on the stage of progression of glucose intolerance in our acromegalic patients.Methods: Acromegaly was diagnosed using standards e...